Monodisperse with narrow size distributions. Electron microscopy, optical spectroscopy, and hydrodynamic diameter data provided with every batch. Available with a wide variety of surfaces.
Your Choice of Solvent
Our dried nanopowders are formulated with polymer or alkanethiol surface coatings which allow the nanoparticles to easily be redispersed as unagglomerated dispersions in a variety of solvents. We have verified the redispersion with transmission electron microscopy (TEM), UV-visible spectroscopy and dynamic light scattering. Buy Now
A wide range of core sizes and shell thicknesses with different surface functionalizations are available. Buy Now
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Need a nanoparticle with a particular size, material or surface coating? Looking for a multi-functional nanoparticle with magnetic or fluorescent components? Want a nanoparticle that binds to a specific target? We specialize in fabricating a wide variety of custom nanomaterials for academic and industrial customers. Buy Now
Gold nanoparticles are one of the most commonly utilized nanomaterials due to their stability and optical properties.
Gold nanopaticles are readily conjugated to antibodies and other proteins due to the affinity of sulfhydyl (-SH) groups for the gold surface, and gold-biomolecule conjugates have been widely incorporated into diagnostic applications, where their bright red color is used in home and point-of-care tests such as lateral flow assays.
Gold nanomaterials can be conjugated to biomolecules to specifically target cancer cells, and used for photothermal cancer therapy, where their tunable optical properties cause them to convert laser light into heat and selectively kill cancerous cells.
Gold nanoparticles have unique optical properties because they support surface plasmons. At specific wavelengths of light the surface plasmons are driven into resonance and strongly absorb or scatter incident light. This effect is so strong that it allows for individual nanoparticles as small as 30 nm in diameter to be imaged using a conventional dark field microscope. This strong coupling of metal nanostructures with light is the basis for the new field of plasmonics. Applications of plasmonic gold nanoparticles include biomedical labels, sensors, and detectors. The gold plasmon resonance is also the basis for enhanced spectroscopy techniques such as Surface Enhanced Raman Spectroscopy (SERS) and Surface Enhanced Fluoressence Spectroscopy which can be used to detect analytes with ultrahigh sensitivity.
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Each batch of gold nanoparticles is extensively characterized using techniques including transmission electron microscopy (TEM), dynamic light scattering (DLS), zeta potential, and UV-Visible spectroscopy. In addition to ensuring that every batch of nanoparticles meets our stringent quality control requirements, customers are provided with batch-specific specification sheets containing representative TEM images, sizing data, hydrodynamic diameter measurements, zeta potential analysis, UV-Visible spectrum, and solution pH.
Surface chemistry and suspension buffer details are provided for each material, and no proprietary coatings or mystery chemicals are used. Gold nanoparticle products are available with a range of capping agents including citrate, tannic acid, polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA), silica, and amine-terminated silica.
Gold nanoparticles are provided in two concentrations, NanoXact (0.05 mg/mL) and BioPure (1 mg/mL). At NanoXact concentrations, the gold particles are a ruby red or yellow/red color in solution depending on their size. The BioPure formulation is 20X more concentrated and is red or red/yellow and opaque. The highly concentrated BioPure formulations are ideal for applications that require high concentrations or low residual reactants including nanotoxicology, environmental studies, and lateral flow assays. Even though the particles are made from a high density material, smaller gold nanoparticles remain suspended in solution. Large gold nanoparticles may settle out of solution, but are easily redispersed by simply shaking the storage vial.
Due to their small size, low mass, and extremely high surface area:volume ratios, once nanoparticles bind together it is often impossible to separate them. Consequently, most dried gold nanopowders that are resuspended consist of clusters of 100's of individual nanoparticles. For many plasmonics and biomedical applications, this agglomeration significantly degrades performance. At nanoComposix we have developed custom processing techniques that allow us to concentrate and purify nanoparticles without inducing agglomeration. The particles can be transferred into a variety of different solvents to enable their integration into a wide variety of systems. In addition, we have developed a surface stabilization technique that allows us to produce dried gold nanoparticles that can be redispersed into individual, monodisperse nanoparticles.
Our nanoparticle chemists will address your technical questions and help you select the optimal nanomaterial for your application.
The following table links nanoparticle size with mass, atomic molarity, mass percent, particle concentration, and peak optical density for both NanoXact and BioPure gold formulations.
|Atomic (Au) Molarity (mmol/L)||Particle
|Au Mass Percent (%)||Max Optical Density (cm-1)||Peak
|5||0.05||0.254||3.95 x 1013||0.005||0.80||520|
|7||0.05||0.254||1.44 x 1013||0.005||0.82||520|
|10||0.05||0.254||4.94 x 1012||0.005||0.82||520|
|12||0.05||0.254||2.86 x 1012||0.005||0.83||520|
|15||0.05||0.254||1.46 x 1012||0.005||0.83||520|
|17||0.05||0.254||1.01 x 1012||0.005||0.84||520|
|20||0.05||0.254||6.18 x 1011||0.005||0.85||520|
|30||0.05||0.254||1.83 x 1011||0.005||1.1||520|
|40||0.05||0.254||7.72 x 1010||0.005||1.1||520|
|50||0.05||0.254||3.95 x 1010||0.005||1.5||525|
|60||0.05||0.254||2.29 x 1010||0.005||1.6||530|
|70||0.05||0.254||1.44 x 1010||0.005||1.6||535|
|80||0.05||0.254||9.65 x 1009||0.005||1.6||545|
|90||0.05||0.254||6.75 x 1009||0.005||1.3||555|
|100||0.05||0.254||4.94 x 1009||0.005||1.0||555|
|Atomic (Au) Molarity (mmol/L)||Particle
|Au Mass Percent (%)||Max Optical Density (cm-1)||Peak
|5||1.0||5.08||7.91 x 1014||0.1||16.0||520|
|7||1.0||5.08||2.88 x 1014||0.1||16.4||520|
|10||1.0||5.08||9.88 x 1013||0.1||16.4||520|
|12||1.0||5.08||5.72 x 1013||0.1||16.6||520|
|15||1.0||5.08||2.92 x 1013||0.1||16.6||520|
|17||1.0||5.08||2.02 x 1013||0.1||16.8||520|
|20||1.0||5.08||1.24 x 1013||0.1||16.9||520|
|30||1.0||5.08||3.66 x 1012||0.1||22.1||520|
|40||1.0||5.08||1.54 x 1012||0.1||22.6||520|
|50||1.0||5.08||7.90 x 1011||0.1||29.1||525|
|60||1.0||5.08||4.58 x 1011||0.1||31.8||530|
|70||1.0||5.08||2.88 x 1011||0.1||31.8||535|
|80||1.0||5.08||1.93 x 1011||0.1||31.5||545|
|90||1.0||5.08||1.36 x 1011||0.1||26.4||555|
|100||1.0||5.08||9.88 x 1010||0.1||20.1||555|
|Product Line||Description||Available Materials||Available Surfaces||CV||Concentration||Available Dried||Buy||NCX University|
|Sterile & guaranteed endotoxin-free||Gold, silver, platinum, magnetite||Multiple||< 18%||1 mg/mL||No||See products||Learn more|
|For bioconjugation (lateral flow assays, etc.)||Gold||Multiple||< 15%||Varies; usually 20 OD||Yes||See products||Learn more|
|Lowest prices & highest concentration||Gold, silver||PVP||< 25%||5 mg/mL||Yes||See products||Learn more|
|Widest combination of materials and surfaces||Gold, silver, silica, platinum, titania, magnetite||Multiple||Varies; usually < 15%||Varies||Yes||See products||Learn more|
|Most monodisperse||Gold||PEG-carboxyl||< 5%||0.05 mg/mL||No||See products||Learn more|
|Do none of these work for you? Request a Custom Nanomaterial|
|We also offer a variety of nanoparticle characterization services|
|Surface||Charge||Characteristics||Available Materials||Buy||NCX University|
|Bare (Citrate)||Easiest standard surface to displace with other molecules.||Gold, silver, platinum||See products||Learn more|
|Aminated (BPEI)||Covalently bound. Conjugatable surface.||Gold, silver||See products||Learn more|
|Carbonate||For biocojugation. Smaller, less complex molecule with a lower affinity to gold nanoparticle surface than citrate.||Gold||See products||Learn more|
|Carboxyl/Lipoic Acid||Covalently bound. Conjugatable surface.||Gold, silver||See products||Learn more|
|Dodecanethiol||Redispersible and stable in non-polar organic solvents.||Gold, silver||See products||Learn more|
|NHS||For quick and easy bioconjugation – no EDC/NHS activation required.||Gold||See products|
|PEG||Highest stability in aqueous buffers and polar organic solvents.||Gold, silver||See products||Learn more|
|Polystyrene||Hydrophobic surface that allows for dispersion in a wide range of polar organic solvents.||Gold||See products||Learn more|
|PVP||Large polymer surface. Stable in a wide variety of solvents.||Gold, silver, magnetite||See products||Learn more|
|Silica Shell||Greatest solvent compatibility. Preserves plasmonic properties upon deposition.||Gold, silver, silica||See products||Learn more|
|Silica Shell (Aminated)||Conjugatable surface. Greatest solvent compatibility. Preserves plasmonic properties upon deposition.||Gold, silver, silica||See products||Learn more|
|Streptavidin||For convenient bioconjugation of any biotinylated antibody, protein, or oligonucleotide.||Gold||See products|
|Tannic Acid||Less easily displaced than citrate but stable in more buffers.||Gold||See products||Learn more|
|Do none of these work for you? Request a Custom Surface|
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